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. 2022 Sep 16;12:62. doi: 10.1186/s13550-022-00934-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Isotype control uptake on PET images of collagen-induced arthritis (CIA) mice. a [⁶⁴Cu]Cu-NOTA-IgG2b imaging 24 h p.i. of the carpal and tarsal joints of control (n = 6) and CIA mice (n = 8). Tracer accumulation is calculated as %ID/joint and %Max ID/g. Each point represents a joint. b Comparison of [⁶⁴Cu]Cu-NOTA-CD4 (n = 23) and isotype control, [⁶⁴Cu]Cu-NOTA-IgG2b (n = 7) uptake in spleen, thymus, liver and blood of CIA mice expressed as %ID/g. Data are presented as mean ± SEM. The significance level is indicated by asterisks (*). p < 0.0001 (****)