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. 2022 Jun 29;29:969–978. doi: 10.1016/j.omtn.2022.06.001

Figure 2.

Figure 2

The ability of APT-β1-OMe and APT-β1-OMe-P to inhibit TGF-β1-induced expression of SMAD2-responsive luciferase reporter

In the left panel, HEK293 cells transfected with the SMAD2-responsive luciferase reporter plasmid were treated with various amounts of TGF-β1. In the right panel, TGF-β1 (80 pM) was added to HEK293 cells, which were transfected with the reporter plasmid, in the presence or absence of various amounts of APT-β1-OMe-P and APT-β1-OMe. The values were expressed as relative luminescent units (RLUs) (shown in %) to the 100 pM (left panel) or 80 pM TGF-β1 level (right panel) without aptamer after subtraction of basal LUs in control cells without treatment. Data represent the mean ± SD (n = 3).