TABLE 2.
Laboratory results of 169 patients with COVID‐19 on day of sample collection
| Laboratory parameter | Thrombosis (N = 58) | No thrombosis (N = 111) | Reference range | p value |
|---|---|---|---|---|
| Coagulation assays, median (range) | ||||
| PT (s) | ||||
| UMC Utrecht | 14.8 (11.9–20.9) | 14.3 (11.7–32.6) | 10.0–13.0 | 0.03 |
| Erasmus MC | 13.2 (10.9–18.2) | 13.2 (11.5–15.8) | 10.9–13.3 | 0.7 |
| aPTT (s) a | ||||
| UMC Utrecht | 39.0 (27.0–60.0) | 35.0 (23.0–105.0) | 24.0–34.0 | 0.2 |
| Erasmus MC | 32.0 (20.0–70.0) | 25.0 (18.0–73.0) | 22.0–32.0 | 0.3 |
| Fibrinogen (g/L), median (range) | 6.7 (1.8–11.9) | 5.8 (2.7–10.0) | 2.0–4.0 | 0.1 |
| D‐dimer (mg/L), median (range) | ||||
| UMC Utrecht | 5.9 (0.4–100.0) | 1.2 (0.2–34.0) | 0.00–0.50 | <0.0001 |
| Erasmus MC | 3.2 (0.2–15.2) | 1.2 (0.3–35.2) | 0.00–0.50 | 0.05 |
| CRP (mg/L), median (range) | 154.5 (1.4–480.0) | 70 (1.4–432.0) | 0–10 | <0.0001 |
| Platelet count (×109/L), median (range) | 259 (51–842) | 283 (96–611) | 150–450 | 0.4 |
| Anti‐FXa levels, b n | ||||
| <0.50 IU/ml | 39 | 56 | ||
| 0.50–0.99 IU/ml | 19 | 54 | ||
| 1.00–1.39 IU/ml | 0 | 1 | ||
Note: Data of PT are missing for 8 patients, aPTT for 46 patients, fibrinogen for 33 patients, D‐dimer for 34 patients, CRP for 2 patients, and platelet count for 4 patients.
Abbreviations: aPTT, activated partial thromboplastin time; CRP, C‐reactive protein; ICU, intensive care unit; PT, prothrombin time.
a
LA‐insensitive aPTT reagent was used.
b
Determined before mixing with normal plasma. Different assays were used for PT, aPTT, and D‐dimer determination, so data for UMC Utrecht and Erasmus MC were separated.