TABLE 3.
Clinical outcomes among patients with iTTP during the post‐index period
| All patients with iTTP diagnosis (n = 666) | Patients with ≥1 iTTP episode (n = 302) | |
|---|---|---|
| Exacerbation, n (%) | N/A | 52 (17) |
| Relapse, n (%) | N/A | 34 (11) |
| Patients with iTTP episode, n (%) a | ||
| ≥1 | 302 (45) | 302 (100) |
| ≥2 | 34 (5) | 34 (11) |
| ≥3 | 9 (1) | 9 (3) |
| ≥4 | 3 (<1) | 3 (1) |
| ≥5 | 3 (<1) | 3 (1) |
| Patients with ≥1 TE event, b n (%) | 139 (21) | 103 (34) |
| Total number of TE events | 193 | 152 |
| TE type, n (%; of total number of TE events) | – | – |
| Cerebral infarction | 106 (55) | 77 (51) |
| Myocardial infarction | 37 (19) | 32 (21) |
| Vascular syndromes | 20 (10) | 17 (11) |
| Pulmonary embolism | 15 (8) | 12 (8) |
| Arterial embolism | 7 (4) | 7 (5) |
| Portal vein obstruction | 5 (3) | 4 (3) |
| Deep vein thrombosis | 2 (1) | 2 (1) |
| Mesenteric vein embolism | 1 (1) | 1 (1) |
| Deaths, n (%) | 167 (25) | 41 (14) |
| Mean (SD) time to death from index date, days | 176.6 (289.1) | 246.6 (360.0) |
| Median (IQR) time to death from index date, days | 33 (13–178) | 90 (23–579) |
| Death within 45 days of index iTTP episode, n (% of total deaths) | 21 (13) | 21 (51) |
| Deaths based on time from index date (months) | ||
| 0–6 | 129 (77) | 28 (68) |
| 7–12 | 11 (7) | 3 (7) |
| 13–18 | 7 (4) | 3 (7) |
| 19–24 | 6 (4) | 2 (5) |
| 25–30 | 7 (4) | NA |
| 31–36 | 5 (3) | NA |
| 37–42 | 1 (1) | NA |
| 43–48 | 1 (1) | NA |
| Mean (SD) age at death, years | 60.6 (15.4) | 59.3 (15.6) |
| Median (IQR) age at death, years | 64 (52–71) | 61 (48–70) |
Abbreviations: IQR, interquartile range; iTTP, immune‐mediated thrombotic thrombocytopenic purpura; NA, not available; SD, standard deviation; TE, thromboembolic.
a
Includes the index episode and any iTTP episode occurring during the follow‐up period.
b
Occurring during the postindex period.