Figure 2.

Macrophage dysregulation in diabetic wounds leads to delayed wound healing

Compared with normal wounds, increased numbers of infiltrated BM-produced monocytes are present in diabetic wounds, which, in turn, leads to a higher number of macrophages (a). The capability of M1 macrophages to phagocytose pathogens is decreased in diabetic wounds (b). Macrophage transition from M1- to M2-like phenotypes is impaired in diabetic wounds, leading to an accumulation of inflammatory M1 macrophages (c). M1, macrophage with a pro-inflammatory phenotype; M2, macrophage with a pro-healing phenotype. Created with BioRender.