Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison of estimated experimental folding free energy changes upon mutation ΔΔGexp, and predicted estimates ΔΔGpred from three different computational methods: (A) a combined molecular simulation and hydrophobic transfer (HT) model, (B) predictions from the FoldX algorithm, and (C) alchemical FEP estimation. In each plot, the dotted line is the least-squares linear fit, and the root mean squared error (RMSE).
