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. 2022 Sep 3;25(10):105057. doi: 10.1016/j.isci.2022.105057

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Loss of mdig expression in triple negative breast cancer (TNBC)

(A) Immunohistochemistry (IHC) of mdig expression in hormone positive breast cancer and TNBC. Both groups of tumors contain mdig positive and mdig negative cancer tissue samples. In hormone positive group, 54% of tumor samples are mdig positive. In TNBC, only 18% of these samples are mdig positive. Scale bar = 50 μm, magnification is 40×.

(B) Kaplan-Meier overall survival (OS) analysis of 1,879 cases of breast cancer with high and low mdig expression. Right two panels show the prognostic outcomes of mdig expression in 201 TNBC cases. Both probes of mdig in the database are shown.

(C) High level of mdig predicts poor survival of the patients without lymph node metastasis (left two panels) but predicts better survival of the patients with lymph node metastasis (right two panels).