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. 2022 Sep 3;25(10):105057. doi: 10.1016/j.isci.2022.105057

Figure 2.

Figure 2

Breast tumor formation in NSG mice injected with WT and mdig KO MDA-MB-231 cells

(A) Photographs of the freshly resected mammary tumors from the mice injected with WT and KO cells, respectively. The WT cells form large tumors than the KO cells. Lower panels show quantification of the tumor size. Data are represented as mean ± SD. Tumors from the KO cells not only grow much slower (left panel) but are significantly smaller in size at the end of experiments (right panel). Only three tumors from each group of mice were shown.

(B) Photographs of the resected axillary and lumbar lymph nodes from the mice received with WT and KO cells. An overall enlargement of lymph nodes in the mice received with KO cells was observed. Bottom panel shows the summary of the tumor size, lymph node and the visually observed metastasis in the mice received with WT and KO cells.