Figure 4.

Quantitative proteomics analysis for protein expression between WT and KO MDA-MB-231 cells

(A) Volcano plot shows increased and decreased proteins in the mdig KO cells (upper panel). Bottom panel shows top-25 the most downregulated (left) and upregulated proteins (right) in the KO cells. Gene names with red color are those genes with decreased enrichment of H3K36me3. Gene names with green color are the genes with an enhanced enrichment of H3K36me3 in the mdig KO cells. Asterisks indicate proteins located in lysosomes. X denotes the proteins that are encoded by genes located in chromosome X.

(B) Ontology GO molecular function assay of the downregulated proteins (upper panel) and the upregulated proteins (bottom panel) in the KO cells.