Figure 7.

Enhanced enrichment of H3K36me3 in the mdig KO cells

(A) ChIP-seq shows global enrichment levels of H3K36me3 on the gene bodies between WT and KO cells (top panel) and Pearson correlation of H3K36me3 between WT and KO cells (bottom panel).

(B) Genome browser screenshots of H3K36me3 between WT and KO cells using examples of chromosomes 9 (left panel) and X (right panel). Red arrows and dashed red boxes show regions in the chromosomes with an enhanced enrichment of H3K36me3 in the KO cells. Typical genes with enhanced enrichment of H3K36me3 are listed at the bottom of the panels.

(C) Ontology molecular function assay of the genes with a more than 2-fold increase of H3K36me3 in the KO cells.

(D) Ontology molecular function assay of the genes with a more than 2-fold decrease of H3K36me3 in the KO cells.