Figure 8.

Correlation between the most increased expression of genes in metastasis and enhanced enrichment of H3K36me3 in the KO cells

(A) Genome browser screenshots of the histone methylation pattern on the selected most upregulated genes in mdig KO cells.

(B) Different degrees of correlation between the upregulated genes and the enhanced enrichment of H3K36me3 in KO cells. The top 50 most upregulated genes in KO cells were analyzed for an increase of H3K36me3. In the top 1 to 15 range, 80% of these genes showed an elevated enrichment of H3K36me3, whereas from top 16 to 50 range, 43% of the genes showed an increase in H3K36me3.

(C) Genome browser screenshots depicts representative downregulated genes with a pronounced diminishment of H3K36me3 in the KO cells.