Table 1.

Characteristics of the cohort with hospital-onset sepsis according to the operating hour of the rapid response team

Variable	All-day group (n = 206)	Non-all-day group (n = 199)	P value
Age, year, mean ± SD	63.2 ± 14.1	66.3 ± 15.1	0.034
Sex, male, n (%)	140 (68.0)	122 (61.3)	0.161
BMI, kg/m2, mean ± SD	21.9 (3.7)	22.2 (3.9)	0.311
CCI, mean ± SD	5.4 (2.7)	5.6 (2.8)	0.582
Comorbidities, n (%)
Cardiovascular disease	33 (16.0)	24 (12.1)	0.252
Chronic respiratory disease	20 (9.7)	25 (12.6)	0.361
Chronic neurologic disease	21 (10.2)	38 (19.1)	0.011
Chronic liver disease	23 (11.2)	31 (15.6)	0.192
Diabetes	62 (30.1)	58 (29.1)	0.834
Chronic renal disease	20 (9.7)	25 (12.6)	0.361
Connective tissue disease	1 (0.5)	4 (2.0)	0.209
Immunosuppressed	10 (4.9)	13 (6.5)	0.466
Hematologic malignancy	46 (22.3)	38 (19.1)	0.422
Solid cancer	105 (51.0)	80 (40.2)	0.030
Suspected site of infection, n (%)*
Pulmonary	63 (30.6)	82 (41.2)	0.026
Gastrointestinal	83 (40.3)	55 (27.6)	0.007
Urinary	15 (7.3)	26 (13.1)	0.054
Skin/soft tissue	11 (5.3)	4 (2.0)	0.076
Other site**	38 (18.4)	41 (20.6)	0.584
Positive blood cultures, n (%)	66 (32.0)	50 (25.1)	0.124
MRSA	0 (0.0)	4 (2.0)	0.057
MDR GNB	4 (1.9)	2 (1.0)	0.685
VRE	21 (10.2)	9 (4.5)	0.029
Septic shock by Sepsis 3, n (%)	108 (52.4)	58 (29.1)	< 0.001
SOFA score, mean ± SD	6.6 ± 2.7	6.3 ± 3.3	0.091
Serum lactate, mmol/l, mean ± SD	4.1 ± 3.4	3.6 ± 2.8	0.145

SD = standard deviation, BMI = body mass index, CCI = Charlson comorbidity index, MDR = multidrug resistant, SOFA = sequential organ failure assessment

*13 patients—4 in the all-day group and 9 in the non-all-day group—had multiple sites of infection

**Other sites of infection include blood-stream infection, catheter-associated infection, and unknown