Table 2.
CN | OA | OA + TCZ-2 | OA + TCZ-4 | OA + DEX-10 | P-value | ||
---|---|---|---|---|---|---|---|
Histopathological | Thickening in the interalveolar septum | 0.60 ± 0.54b | 2.40 ± 0.54a | 1.40 ± 0.54ab | 1.00 ± 0.70b | 0.80 ± 0.44b | 0.006 |
Peribronchial cell infiltration | 0.60 ± 0.54b | 2.88 ± 0.40a | 1.20 ± 0.44b | 1.00 ± 0.70b | 1.00 ± 0.70b | 0.006 | |
Hyperemia in vessels | 1.20 ± 0.44b | 2.60 ± 0.54a | 1.40 ± 0.54b | 1.40 ± 0.89b | 1.40 ± 0.54b | 0.039 | |
Immunohistochemical | TNF-a | 0.50 ± 0.57b | 2.75 ± 0.50a | 1.75 ± 0.95ab | 2.5 ± 1.00ab | 1.5 ± 1.00ab | 0.034 |
IL-6 | 1.00 ± 1.15b | 2.50 ± 0.57a | 1.25 ± 0.5ab | 0.50 ± 0.57b | 0.75 ± 0.50b | 0.41 | |
IL-8 | 0.75 ± 0.50b | 2.5 ± 0.57a | 2.00 ± 0.81ab | 0.25 ± 0.50b | 0.75 ± 0.95b | 0.13 |
a, bP < 0.05. All values are given as mean ± standard deviation