Skip to main content
. Author manuscript; available in PMC: 2022 Sep 17.
Published in final edited form as: J Am Chem Soc. 2021 Aug 17;143(34):13473–13477. doi: 10.1021/jacs.1c05146

Figure 1.

Figure 1.

Structures of CHX (1) and C13-substituted CHX derivatives. (A) CHX (1), C13-substituted derivatives (2, 3), and lactimidomycin (LTM, 4) bind the ribosome E site, but have different effects on translation. (B) A semi-synthetic route from 1 allows access to C13-modified derivatives.