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. 2022 Sep 14;10:e14010. doi: 10.7717/peerj.14010

Figure 3. 5-Methylindole exhibited bactericidal activity against antibiotic-resistant/tolerant bacteria.

Figure 3

(A–C) Survival of MRSA (panel A), K. pneumoniae (panel B) and M. tuberculosis H37Ra (an avirulent strain, panel C) in stationary-phase following a 3-h treatment with indole, 2-methylindole or 5-methylindole at increasing concentrations (0, 1, 2, 3, 4, 5, 6, 7 and 8 mM). (D, E) Survival of S. aureus nutrient shift-induced (panel D) and starvation-induced persister cells (panel E) following a 3-h treatment with indole, 2-methylindole or 5-methylindole at increasing concentrations (0, 1, 2, 3, 4, 5, 6, 7 and 8 mM). Data represent the means ± SD of three replicates of one independent experiment. An asterisk (*) represents no detectable colonies on LB dish when 5 μL treated cells were spot plated.