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Molecular structure of BSG-2. BSG-2 contains an extracellular region, a TM region, and an intracellular region. The extracellular domain includes the Ig1 and Ig2 domains. The Ig1 domain can stimulate the production and activation of MMPs, and the Ig2 domain enables CD147 to exert different biological activities by interacting with different molecules. There are three sites in the Ig1 and Ig2 domains that can be modified by glycosylation.
