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. Author manuscript; available in PMC: 2022 Sep 17.
Published in final edited form as: Neurobiol Dis. 2021 Nov 24;162:105562. doi: 10.1016/j.nbd.2021.105562

Fig. 3.

Fig. 3.

3xTg-AD CA1 cells exhibit altered calcium activities and impaired spatial coding during open field exploration. A. Violin plots of calcium event rates of all neurons from different groups of mice. Only the periods with movement speeds higher than 5 mm/s were used for event rate calculation, and event rates from trials within arenas of the same geometry were averaged. B. Violin plots of calcium event amplitudes of all neurons from different groups of mice. C. Cumulative distribution plots of spatial information scores (in bits/event) for all place cells from Non-Tg old, 3xTg-AD old, Non-Tg young and 3xTg-AD young mice exploring in both square and circle arenas. D. Cumulative distribution plots of sparsity values of all neurons for all Non-Tg old, 3xTg-AD old, Non-Tg young and 3xTg-AD young mice in both square and circular arenas. E. Cumulative distribution plots of spatial coherence values of all neurons for all Non-Tg old, 3xTg-AD old, Non-Tg young and 3xTg-AD young mice, in both square and circular arenas. LME analyses were used for A-B; two-sample Kolmogorov-Smirnov tests were used for C-E. *, ** and *** indicate the significance levels with the respective p values of <0.05, <0.005, and < 0.0005.