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. 2022 Sep 17;8:387. doi: 10.1038/s41420-022-01185-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Overlays of averaged ERG signals of Cnga1^Y509C/Y509C mice (red) compared to wild-type mice (black) at postnatal week 3 (PW3), postnatal month 1 (PM1), PM3, PM6, PM9 and PM12 at different light intensities. Vertical dotted lines mark the time points of light stimulation. Homozygous mutant mice show almost no (rod-mediated) response at low light intensities (0.01 and 0.03 cd s m-2) and also lose cone-mediated response between PM6 and PM9. B–G Quantification of a-wave and b-wave amplitudes of Cnga1^Y509C/Y509C mice (red) compared to wild-type mice (black) at different ages. a-wave (B) and b-wave (E) amplitudes were massively reduced in Cnga1^Y509C/Y509C mice compared to wild types for all light intensities at PM1. Rod-mediated responses for the a-wave (C) and b-wave (F) at a low light intensity (0.03 cd s m-2) as well as cone-mediated response for a-wave (F) at a high light intensity (10 cd s m-2) were reduced from the first measurement at PW3, while cone-mediated response for the b-wave (G) decreased over time. Wild-type mice: n = 10; Cnga1^Y509C/Y509C mice: n = 12. Values are given as mean ± SEM.