Skip to main content
. 2022 Sep 17;8:387. doi: 10.1038/s41420-022-01185-0

Fig. 6. Cnga1Y509C/Y509C mice show a reduced photoreceptor layer thickness.

Fig. 6

A Representative retina morphology images of wild-type mice and mutants showing progressive thinning of the ONL layer in the Cnga1Y509C/Y509C mice. Representative SD-OCT images of Cnga1Y509C/Y509C and wild-type mice up to 12 months of age demonstrating a massive reduction of photoreceptor layer thickness in homozygous mutant mice (C, E) compared to wild-type mice (B, D). Black bars in close-ups D and E mark the thickness of the photoreceptor layer. RPE, retinal pigment epithelium; OS, outer segments; ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer. F Degeneration progress of photoreceptor layer thickness in homozygous mutant mice (red) compared to wild-type mice (black) from 3 weeks until 12 months of age. Wild-type mice: n = 10; Cnga1Y509C/Y509C mice: n = 12. Values are given as mean ± SD. Scale bar in A marks 100 µm.