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. 2022 Sep 17;5:984. doi: 10.1038/s42003-022-03883-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Domain architecture schematic of the IST superfamily with the 4HB, hinge, and Ig-like domains colored orange, green, and blue, respectively. IZUMO4 has a unique C-terminal region, which is colored black. Confirmed and putative disulfide bonds are shown in solid and dashed magenta lines, respectively. b Ribbon diagrams of the IST superfamily of gamete fusion-associate proteins IZUMO1 (PDB: 5F4E), SPACA6, IZUMO2 (AlphaFold DB: AF-Q6UXV1-F1), IZUMO3 (AlphaFold DB: AF-Q5VZ72-F1), IZUMO4 (AlphaFold DB: AF-Q1ZYL8-F1), and TMEM95 (AlphaFold DB: AF-Q3KNT9-F1) shown in the same color scheme as in panel A. Disulfide bonds are shown in magenta. Transmembrane helices of TMEM95, IZUMO2, and IZUMO3 are not shown.