Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 17;5:984. doi: 10.1038/s42003-022-03883-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Sequence alignment of SPACA6 ectodomains from twelve different species prepared using CLUSTAL OMEGA. Most conserved positions according to ConSurf analysis are colored blue. Cysteine residues are highlighted in red. Domain boundaries and secondary structure elements are shown on top of the alignment with arrows indicating beta strands and a wave indicating helices. NCBI accession IDs for included sequences are as follows: human (Homo sapiens, NP_001303901), mandrill (Mandrillus leucophaeus, XP_011821277), capuchin (Cebus imitator, XP_017359366), horse (Equus caballus, XP_023506102), orca (Orcinus orca, XP_012394831), sheep (Ovis aries, XP_014955560), elephant (Loxodonta africana, XP_010585293), dog (Canis lupus familiaris, XP_025277208), mouse (Mus musculus, NP_001156381), Tasmanian devil (Sarcophilus harrisii, XP_031819146), platypus (Ornithorhynchus anatinus, XP_039768188), and bull frog (Bufo bufo, XP_040282113). Numbering is based on the human sequence. b Surface representation of the SPACA6 structure oriented with the 4HB at the top and the Ig-like domain at the bottom and colored based on conservation scores from the ConSurf server. Most conserved portions are colored blue, portions with intermediate levels of conservation are white, and least conserved portions are yellow. Cysteines are colored magenta. Three surface patches showing high levels of conservation are shown in the insets labeled Patches 1, 2 and 3. A cartoon representation of the 4HB is shown in top-right inset (same color scheme).