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. 2022 Sep 17;5:984. doi: 10.1038/s42003-022-03883-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — H-DXMS profiles of a SPACA6 and b IZUMO1. Percentage deuteration exchange was determined at indicated time points. Hydrogen-deuterium exchange levels are color coded in a gradient scale from blue (10%) to red (90%). Black boxes indicate areas of high exchange. The 4HB, hinge and Ig-like domain boundaries observed in the crystal structures are shown above the primary sequence. Deuterium exchange levels at 10 s, 1000 s, and 100,000 s are mapped onto a ribbon diagram overlayed with the transparent molecular surface of SPACA6 and IZUMO1. Portions of the structure with deuterium exchange levels below 50% are colored white. Areas above 50% H-DXMS exchange are colored on the gradient scale.