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. 2022 Sep 17;12:15636. doi: 10.1038/s41598-022-19654-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of genes associated with CHD2 binding during hcIN differentiation. (A–F) Gene ontology (GO) enrichment analysis of genes with a promoter proximal CHD2 peak uniquely in (A, B) hESCs, (C, D) hMGEs, or (E, F) hcINs. − Log10 p values for top enriched terms are shown. (G, H) Gene networks generated from a single representative GO term. In (G), the hESC ‘unique’ CHD2-bound gene network was generated by focusing on intracellular junction-related genes. In (H), the hcIN ‘unique’ CHD2-bound gene network was generated by focusing on synapse-related genes.