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. 2022 Sep 17;12:15636. doi: 10.1038/s41598-022-19654-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of candidate TFs that may co-bind the genome with CHD2 during hcIN differentiation. (A–C) Predicted transcription factor (TF) binding motifs under CHD2 peaks unique to (A) hESCs, (B) hMGEs and (C) hcINs. Adjusted p-values, the percentage of peaks with each TFBS, and the TF class are shown (HD = homeodomain, ZF = Zinc finger, FH = forkhead). (D) Expression changes of up-regulated TFs from hESC (D0) to hMGE (D15). Only TFs with a RPKM value greater than 1 (i.e. log2 RPKM > 0) and a positive fold change from D0 to D15 (i.e. log2 FC > 0) are shown. (E) Expression changes of up-regulated TFs from hMGE (D15) to hcIN (D35). Only TFs with a RPKM value greater than 1 (i.e. log2 RPKM > 0) and a positive fold change from D15 to D35 (i.e. log2 FC > 0) are shown.