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. 2022 Sep 17;12:15636. doi: 10.1038/s41598-022-19654-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression changes in hMGEs and hcINs with CHD2 haploinsufficiency. (A, B) Gene expression differences (log2 FC) between wild type (WT) and mutant (CHD2^+/−) in (A) hMGEs and (B) hcINs. Red: down-regulated genes in the mutant (CHD2^+/−); green: up-regulated genes in the mutant (CHD2^+/−). (C, D) Distribution across the 12 previously identified WT gene expression clusters for differentially expressed genes (DEGs) obtained in WT versus CHD2^+/− comparisons at the (C) hMGE and (D) hcIN stage. (E–G) Gene ontology (GO) enrichment analysis of DEGs down regulated in CHD2^+/− compared to WT models at the (E) hMGE or (F, G) hcIN stage. For hcINs, DEGs that mapped to WT expression (F) clusters 4, 6, 8 and 10, versus (G) cluster 12 were analyzed separately. (H) Gene ontology (GO) term analysis of DEGs that were upregulated in the CHD2^+/− compared to the WT model at the hcIN stage.