Table 2.
Independent predictors of in-hospital mortality by univariate and multivariate Cox regression analysis
| Variables | HR (95%CI) | P |
|---|---|---|
| Univariate Cox analysis | ||
| APACHE II score | 1.046 (1.001–1.092) | 0.043 |
| Albumin | 1.016 (0.963–1.072) | 0.561 |
| Creatinine | 1.001 (1.000–1.002) | 0.214 |
| MPV | 1.712 (1.358–2.159) | 0.000 |
| Leukocyte | 0.982 (0.908–0.993) | 0.657 |
| CRP | 1.011 (1.003–1.020) | 0.011 |
| Vasopressor use | 2.087 (1.115–3.908) | 0.021 |
| CRRT | 3.134 (1.193–8.232) | 0.003 |
| CKD | 2.052 (1.017–4.140) | 0.045 |
| Septic shock | 2.538 (1.371–4.697) | 0.003 |
| AKI | 1.949 (1.051–3.612) | 0.034 |
| PaO2/FIO2 | 0.982 (0.971–0.993) | 0.002 |
| Age | 1.028 (1.000–1.057) | 0.052 |
| Lactate | 1.080 (0.953–1.223) | 0.228 |
| sex | 0.849 (0.447–1.613) | 0.849 |
| Multivariate Cox* analysis | ||
| MPV | 1.741 (1.267–2.393) | 0.001 |
| PaO2/FIO2 | 0.984 (0.972–0.997) | 0.015 |
| CRP | 1.013 (1.003–1.022) | 0.008 |
| CRRT | 5.455 (1.676–17.759) | 0.005 |
*Covariates included in multivariate analysis: APACHE II score, MPV, CRP, PaO2/FIO2, vasopressor use, CRRT, CKD, AKI, septic shock
APACHE II acute physiology and chronic health evaluation II; MPV mean platelet volume; CRP C-reactive protein; CRRT continuous renal replacement therapy; CKD chronic kidney disease; AKI acute kidney injury; PaO2 arterial oxygen tension; FiO2 fraction of inspired oxygen;