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. Author manuscript; available in PMC: 2022 Sep 18.
Published in final edited form as: J Med Chem. 2022 Jun 28;65(15):10506–10522. doi: 10.1021/acs.jmedchem.2c00652

Table 1.

SARs of Compounds with Various Covalent Warheads

graphic file with name nihms-1833952-t0018.jpg
Compound X R G9a adduct (%)a
1 N graphic file with name nihms-1833952-t0019.jpg 40%
2 N graphic file with name nihms-1833952-t0020.jpg ND
3 N graphic file with name nihms-1833952-t0021.jpg ND
4 N graphic file with name nihms-1833952-t0022.jpg ND
5 N graphic file with name nihms-1833952-t0023.jpg ND
6 N graphic file with name nihms-1833952-t0024.jpg ND
7 N graphic file with name nihms-1833952-t0025.jpg ND
8 (MS8511) C graphic file with name nihms-1833952-t0026.jpg 50%
a

Formation of G9a adduct was monitored by mass spectrometry. G9a adduct (%) = (G9a adduct/(G9a + G9a adduct)) × 100.

ND: G9a adduct was not detected.