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. 2022 Sep 5;13:944886. doi: 10.3389/fphar.2022.944886

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Copyright © 2022 Ma, Zhang, Kuang, Xu, Ye, Li, Qu, Han, Kan and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SESN2 knockdown weakened the effects of EMPA on inflammation and lipid accumulation. (A) The hepatocytes were transfected with siSESN2 for 48h, followed by qPCR analysis. (B) Western blot detection of SESN2 in HepG2 cells expressing SESN2-siRNA or control-siRNA. (C) Western blot analysis of SESN2 protein levels treated with or without EMPA after transfected with SESN2-siRNA or control-siRNA. (D–I) Western blot analysis of p-mTOR, p-AMPK and HO-1 protein levels after transfected with SESN2-siRNA or control-siRNA. (J, K) Inflammatory factors partly did not decrease in HepG2 cells with EMPA-siSESN2. (L–N) Fatty acid generation and β-oxidation in HepG2 cells treated with EMPA after SESN2-siRNA or control-siRNA. The data are expressed as the mean ± SEM; *p < 0.05 vs. siNC and #p < 0.05 . siNC + PA group; $p < 0.05 vs. siSESN2 002B; PA; &p < 0.05 vs. siNC + PA + EMPA group.