Table 1.

The functional potentials in PD and PD with T2D communities.

Functional potentials	PD vs PD with T2D	Reference
virulence genes	colonization factor, fimbriae, hly, iuc, pap, pilin and srt	PD [Li]
Amino acid metabolism	Lysinedecarboxylase; L-alanine dehydrogenase; biosynthetic arginine decarboxylase, PLP-binding; argininosuccinate lyase
glycosaminoglycan degradation	N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase, b-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase, N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase;
Pyrimidine metabolism	thymidine phosphorylase, uridine phosphorylase;
Organic acids	b-ketoacyl-ACP synthase III, butyrate kinase, butyrate-acetoacetate CoA-transferase;
Carbohydrate degradation	Not significant
Lipid metabolism	either lipid metabolism, arachidonic acid metabolism	[Shi]
carbohydrate metabolism	inositol phosphate metabolism
Signal pathway*	[PD with T2D] Two component system
cell motility*	[PD, PD with T2D both] bacterial motility, flagellar assembly, bacterial chemotaxis

*Prevalent in the periodontitis statein T2D and non-diabetic (ND).

PLP, pyridoxal-5’-phosphate; ACP, β-ketoacyl-acyl-carrier-protein.