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. 2022 Sep 5;12:855008. doi: 10.3389/fcimb.2022.855008

Figure 5.

Figure 5

Sin A mediates LPS-TLR4 signaling to ameliorate HFD-induced obesity and insulin resistance in NAFLD mice. Vehicle-group mice were treated with vehicle (HFD) or Sin A (80 mg/kg); CLI-095 group mice were treated with vehicle (HFD) or Sin A (80 mg/kg). (A) Body weight evaluation of 6 weeks for HFD, Sin A, CLI-095 and CLI-095 + Sin A groups (n=5–8 per group). (B) Serum free glycerol levels and free fatty acids (FFAs) (n=5–7 per group). (C) Fasting blood glucose (FBG) levels (n=7–10). Results of (D) glucose tolerance test (GTT) and (E) insulin tolerance test (ITT) (n=7–8 per group). (F) Heat expenditure and its respective average of light cycle and dark cycle (n=5–6 per group). Values represent mean ± SD. Significance was determined by two-way ANOVA for the multiple-group comparisons. p*<0.05; **p<0.01; ***p<0.001. FFA, fatty fat acid; FBG, fasting blood glucose; GTT, glucose tolerance test; ITT, insulin tolerance test.