Table 2.
Changes in parameters of the patients between the visits (parameters with normal distribution)
| Day 1, Mean ± SD | Day 34, Mean ± SD | Difference day1 vs day34 (Mean ± SD) | 95% CI | 90% CI | Improvement, % | P- value day1 vs day34 | |
|---|---|---|---|---|---|---|---|
| CDAI (n = 16) | 8.31 ± 7.41 | 5.12 ± 6.05 | 3.19 ± 4.50 | 0.79 to 5.58 | – | 38.4 | p = 0.013 |
| SDAI (n = 16) | 9.06 ± 7.73 | 5.44 ± 6.54 | 3.62 ± 6.05 | 0.40 to 6.85 | – | 39.9 | p = 0.030 |
| PtGADA (n = 17) | 37.8 ± 28.6 | 34.3 ± 25.2 | 3.47 ± 25.0 | − 9.39 to 16.3 | − 7.12 to − 14.1 | 9.18 | p > 0.05 |
| PPAIN (n = 17) | 35.2 ± 27.9 | 33.7 ± 23.1 | 1.5 ± 24.2 | − 10.9 to − 14.0 | − 8.75 to 11.8 | 4.34 | p > 0.05 |
| RADAI-5 (n = 12) | 3.77 ± 1.93 | 3.17 ± 1.98 | 0.60 ± 0.95 | − 0.0034 to 1.20 | 0.11 to 1.09# | 15.9 | P = 0.051 |
| BFI (n = 17) | 3.88 ± 2.69 | 3.86 ± 2.20 | 0.02 ± 1.62 | − 0.81 to 0.85 | − 0.66 to 0.70 | 0.49 | p > 0.05 |
| PHQ-9 (n = 17) | 7.41 ± 3.87 | 6.41 ± 2.61 | 1.00 ± 2.18 | − 0.12 to 2.12 | 0.08 to 1.92a | 13.5 | p > 0.05 |
Bold values indicate clinical and/or statistical significance
aconfidence intervals exclude 0 but cross the MCID (1.7 for PHQ-9, D. Kounali, 2020, not identified for RADAI-5)
SDAI simple disease activity index, CDAI clinical disease activity index, PtGADA patient’s global assessment of disease activity, PPAIN patient’s global assessment of pain intensity, RADAI5 rheumatoid arthritis disease activity index-5, BFI brief fatigue inventory, PHQ9 patient health questionnaire-9