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. 2022 Sep 15;40(1):47–76. doi: 10.1007/s11095-022-03385-w

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Interaction of i.v. injected targeted nanoparticles with blood components and consequences for the delivery process. Formation of protein corona leads to reduced intended targeting ability due to masked ligands. Protein corona may lead to transport to other cells or uptake via receptors recognizing plasma proteins. Additionally, endosomal escape can be hampered by protein layer. Created with BioRender.com