Table I.

Characteristics of Cellular Uptake via Clathrin- and Caveolae-Mediated Endocytosis

	Clathrin-mediated endocytosis	Caveolae-mediated endocytosis
Vesicles for transport	Clathrin-coated vesicle	Caveosome
Examples for receptors	TfR, ASGPR, LDLR	Folate receptor, VEGFR, Interleukin-2
Tolerated nanoparticle size	Up to 200 nm	200 to 500 nm
Intracellular fate of cargo	Formation of endosomes, maturation to late endosomes, lysosomal degradation or endosomal escape	Transport to endoplasmic reticulum, Golgi apparatus, facilitated delivery to nucleus