Table 2.
Comparison of semen analysis results of men vaccinated with at least two doses of SARS-CoV-2 mRNA with semen samples pre-vaccination and post-vaccination
| Parameter | Pre-vaccination | Post-vaccination* | P value |
|---|---|---|---|
| Entire cohort (n = 58) | |||
| Semen parameters | |||
| Volume (ml) | 2.9 ± 1.4 (3.0) | 2.9 ± 1.6 (3.0) | 0.956 |
| Concentration (million/ml) | 42.9 ± 37.9 (33.5) | 51.5 ± 46.2 (48.0) | 0.060 |
| Motility (%) | 42.5 ± 23.1 (44.5) | 44.3 ± 23.4 (43.0) | 0.790 |
| Normal morphologya (%) | 8.8 ± .16.6 (4.0) | 6.6 ± 8.8 (3.5) | 0.132 |
| Total motile count (million) | 55.7 ± 57.9 (30.3) | 71.1 ± 77.1 (39.5) | 0.187 |
| Men who received 3 vaccinations (n = 47) | |||
| Semen parameters | |||
| Volume (ml) | 2.9 ± 1.5 (3.0) | 2.9 ± 1.7 (3.0) | 0.870 |
| Concentration (million/ml) | 42.0 ± 38.7 (30.0) | 54.7 ± 47.5 (50.0) | 0.017 |
| Motility (%) | 41.4 ± 21.9 (44.0) | 44.0 ± 25.0 (43.7) | 0.706 |
| Normal morphologya (%) | 6.2 ± 11.9 (3.0) | 7.1 ± 9.2 (4.0) | 0.054 |
| Total motile count (million) | 49.0 ± 53.1 (29.8) | 71.0 ± 73.2 (44.3) | 0.064 |
Data presented as mean ± SD (median)
aMorphology data was available for 8 patients in the entire cohort and for 7 patients in the three vaccination group