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. 2022 Sep 16;44(5):2347–2360. doi: 10.1007/s11357-022-00649-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Sequence of resident IgG reactivation in severe COVID-19. In 7 out of 29 cases, we detected changes in the anti-cardiac autoantibody profile during in-hospital treatment of severe COVID-19 patients. Identifiers of the serum samples (8 digit numbers) are shown above the blots. Below the identifiers, the days after the first blood sampling (in-hospital treatment) are shown. Note, samples were ordered on the gels according to identifier number, which was not chronological in some cases. Differences in anti-cardiac autoantibody profiles are indicated by arrows superposed on the immunoblots. Controls represented healthy individuals, without SARS-CoV-2 infection