Table 3.

Diagnostic performance analysis of serum parameters and severity score for CAP patients

	Prediction of mortality						Prediction of ICU admission
	Cut-off value	AUC (95% CI)	AUC (95% CI) §	Sensitivity (%)	Specificity (%)	Youden index	Cut-off value	AUC (95% CI)	AUC (95% CI) §	Sensitivity (%)	Specificity (%)	Youden index
NMI (pg/ml)	55.48	0.91 (0.86–0.96)	0.91 (0.85–0.95)	87.10	85.12	0.72	55.48	0.92 (0.88–0.97)	0.92 (0.88–0.96)	86.96	88.22	0.75
PCT (ng/ml)	0.89	0.79** (0.70–0.88)	0.80 (0.70–0.88)	64.52	86.61	0.51	0.80	0.80** (0.72–0.88)	0.80 (0.73–0.88)	65.32	87.76	0.53
CRP (mg/l)	125.1	0.78** (0.69–0.87)	0.78 (0.68–0.86)	61.29	75.12	0.36	123.5	0.76*** (0.69–0.84)	0.76 (0.69–0.83)	56.51	85.30	0.42
WBC (10^9/l)	13.15	0.59*** (0.47–0.71)	0.59 (0.47–0.70)	35.48	84.81	0.20	14.85	0.58*** (0.48–0.69)	0.58 (0.47–0.68)	32.61	90.20	0.23
Neutrophils (10^9/l)	5.55	0.65*** (0.54–0.75)	0.65 (0.54–0.74)	80.65	45.73	0.26	11.20	0.63*** (0.53–0.72)	0.63 (0.52–0.72)	36.96	87.05	0.24
NCP(%)	77.15	0.78** (0.70–0.86)	0.78 (0.70–0.85)	90.32	58.84	0.49	81.45	0.73*** (0.65–0.82)	0.73 (0.65–0.82)	69.57	72.33	0.42
PSI	3.5	0.85&& (0.77–0.94)	0.85 (0.77–0.92)	88.43	77.42	0.66	3.5	0.84&&& (0.77–0.90)	0.84 (0.77–0.90)	65.22	89.66	0.55
N-PSI	3.5	0.91 (0.86–0.96)	0.91 (0.86–0.95)	86.78	83.87	0.71	2.5	0.90 (0.86–0.94)	0.90 (0.86–0.93)	91.30	74.71	0.66
CURB65 score	1.5	0.86## (0.77–0.95)	0.86 (0.76–0.93)	83.87	87.60	0.71	1.5	0.84### (0.76–0.91)	0.84 (0.76–0.90)	73.91	89.37	0.63
N-CURB65 score	2.5	0.93 (0.89–0.97)	0.93 (0.89–0.96)	83.87	92.84	0.77	1.5	0.92 (0.89–0.96)	0.92 (0.89–0.95)	80.43	86.49	0.67

N-CURB65: combined NMI with CURB65 score, N-PSI: combined NMI with PSI; *: P < 0.05, **: P < 0.01, ***: P < 0.001 compared with NMI using the z statistic; ^&&: P < 0.01, ^&&&: P < 0.001 compared with N-PSI using the nonparametric method of DeLong et al.; ^##: P < 0.01, ^###: P < 0.001 compared with N-CURB65 score using the nonparametric method of DeLong et al., §: Internally validated AUC with 95% CI by bootstrap