Figure 1.

Serum chemistry values

Serum alanine transaminase (ALT), aspartate transaminase (AST), and gamma-glutamyl transferase (GGT) are shown in the upper panel for both subjects. Normal values are as follows: <40 U/L ALT, 15–50 U/L AST, and 8–78 U/L GGT. Creatine kinase (CK) values are plotted in the lower panel for both subjects. Dotted horizontal lines mark the upper boundary of the normal CK range (37–430 U/L). The dashed vertical steroid taper line marks the time point when gradual steroid dose tapering from the post-gene-transfer dose (of 1 mg/kg) began for each subject.