Table 2.
Overview of the formulation composition, the extrusion (Text) and IM temperatures (TIM) (°C). F, FM and FC stands for formulations prepared using homopolymer, polymer mixtures, and co-polymers, respectively.
| MPT | MTF | THA | PnPrOx | PcPrOx | PsecBuOx | PEtOx | Text (°C) | TIM (°C) | |
|---|---|---|---|---|---|---|---|---|---|
| F1 | 70 | – | – | 30 | – | – | – | 110 | 130 |
| F2 | 70 | – | – | 30a | – | – | – | 110 | 130 |
| F3 | 70 | – | – | – | – | 30 | – | 130 | 150 |
| F4 | – | 70 | – | 30 | – | – | 130 | 160 | |
| F5 | – | 70 | – | – | – | 30 | – | 150 | 190 |
| F6 | – | 70 | – | – | – | 24 | 6 | 150 | 200 |
| F7 | – | 70 | – | – | – | 22.5 | 7.5 | 150 | 200 |
| F8 | – | – | 70 | 30 | – | – | – | 130 | 150 |
| F9 | – | – | 80 | 20 | – | – | – | – | – |
| F10 | – | – | 70 | – | 30 | – | – | – | – |
| FM1 | – | – | 70 | 7.5 | – | – | 22.5 | 160 | 180 |
| FM2 | – | – | 70 | 15 | – | – | 15 | 150 | 170 |
| FM3 | – | – | 70 | 22.5 | – | – | 7.5 | 140 | 160 |
| FC1 | – | – | 70 | 7.5 | – | – | 22.5 | 160 | 180 |
| FC2 | – | – | 70 | 15 | – | – | 15 | 150 | 170 |
| FC3 | – | – | 70 | 22.5 | – | – | 7.5 | 140 | 160 |
| FR | Glucophage™ SR 500 (1/2 tablet) | ||||||||
a
F2 was prepared using 80 kDa PnPrOx while in all other formulations, 50 kDa PnPrOx was used.