Figure 2.

Patterns of functional connectivity (FC) during transition from (a) healthy control, (b) asymptomatic SCC (mJOA = 18), (c) mild DCM (15 ≤ mJOA ≤ 17), (d) to moderate/severe DCM (mJOA ≤ 14). Patterns were characterized using representative brain FCN with regions seeded from anatomical regions that are known to often be explicitly associated with DCM, as well as from regions that have been demonstrated in previous studies to undergo cortical morphological changes as a result of DCM. Top row of images denotes anatomic regions with high betweenness and degree centrality. Middle row denotes the transitional matrix associated with worsened severity, with red connections indicating strengthening connectivity and blue connections indicating weakening connectivity. Bottom row illustrates the anatomy of these changes in connectivity as DCM evolves and becomes more symptomatic.