Fig. 7.

Adaptability and biocompatibility of TWNDs therapy. (A–B) Schematic illustration of pathophysiological changes in kidneys of AKI before (A) and after (B) the application of TWNDs. (C) Serum levels of d CRE and BUN in normal mice or AKI mice at 24 h after different treatment. (D) HE staining of kidney tissues from each group. Yellow arrows indicate the damaged tubular epithelial cells and black stars indicate tubular casts. Scale bar: 20 μm. (E) Tubular injury score of each group in HE staining. (F) WB analysis of BAX, BCL-2, Cyt c, KIM-1 and NGAL proteins in renal tissue homogenate from each group. (G) Quantification of the protein immunoblots of BAX, BCL-2, Cyt c, KIM-1 and NGAL. Data represent means ± S.D. from six independent replicates. (**P < 0.01, ***P < 0.001 vs AKI + PBS group, ^##P < 0.01, ^###P < 0.001 vs PBS group).