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. 2022 Aug 31;65:101587. doi: 10.1016/j.molmet.2022.101587

Table 2.

(A) Expression of pyroptotic components in cancers. (B) The pathway of different cancers.

Cancer type Level of pyroptotic components Associated consequences References
(A)
Esophagus cancer NLRP3↑ cell death and Barrett's esophagus [61]
Upregulated GSDME transit the apoptosis to pyroptotic-signaling pathways [60]
Gastric cancer GSDMD↓ cancer cell proliferation [62]
GSDMA↓ anti-oncogenic factor [70,71]
GSDMB↑ control tumor infringement [49]
GSDMC cancer suppressor gene [73]
DFNA5/GSDME signaling pathway pyroptosis facilitates GC progression [62]
Hepatocellular carcinoma Caspase-1 protein↓ Tumor proliferation [80,84]
NLRP3↓ Increase HCC etiology and progression [81,82]
AIM2↑ Promote pyroptosis and antitumor effects [85,87]
Colorectal cancer Caspase-1↑ Promote epithelial cell proliferation and apoptosis [54]
Lack of AIM2 Poor prognosis in CRC [89]
NLRP1↓ Tumor progression [88,91]
GSDMC↓ Tumor cell proliferation [73]
GSDMD↓ Poor prognosis in CRC [93]
GSDME↑ Increase proliferation [94]
Lung cancer GSDMD↑ Tumor proliferation [95,96]
Knocking out GSDME Flip from apoptosis to pyroptosis [97]
Cervical cancer Caspase-1↑ Lower tumor weight and volume [105]
GSDMD↑ Lower tumor weight and volume [92,105]
NLRP3↑ Lower tumor weight and volume [105,106]
Ovarian cancer GSDME↓ OC progression [109]
GSDMD↓ OC progression [110]
Caspase-4↓ OC progression [110]
Breast cancer GSDMB↑ Metastasis [117]
GSDME↓ Metastasis [78]
GSDMD↑ Caustic death [119]
Skin cancer GSDMC↓ Invasion and metastasis [73]
Cancer types The canonical inflammasome pathway The noncanonical inflammasome pathway Other pathways
(B)
Esophagus cancer
Gastric cancer
Hepatocellular carcinoma
Colorectal cancer
Lung cancer
Cervical cancer
Ovarian cancer
Breast cancer
Skin cancer