(A) |
Esophagus cancer |
NLRP3↑ |
cell death and Barrett's esophagus |
[61] |
|
Upregulated GSDME |
transit the apoptosis to pyroptotic-signaling pathways |
[60] |
Gastric cancer |
GSDMD↓ |
cancer cell proliferation |
[62] |
|
GSDMA↓ |
anti-oncogenic factor |
[70,71] |
|
GSDMB↑ |
control tumor infringement |
[49] |
|
GSDMC |
cancer suppressor gene |
[73] |
|
DFNA5/GSDME signaling pathway |
pyroptosis facilitates GC progression |
[62] |
Hepatocellular carcinoma |
Caspase-1 protein↓ |
Tumor proliferation |
[80,84] |
|
NLRP3↓ |
Increase HCC etiology and progression |
[81,82] |
|
AIM2↑ |
Promote pyroptosis and antitumor effects |
[85,87] |
Colorectal cancer |
Caspase-1↑ |
Promote epithelial cell proliferation and apoptosis |
[54] |
|
Lack of AIM2 |
Poor prognosis in CRC |
[89] |
|
NLRP1↓ |
Tumor progression |
[88,91] |
|
GSDMC↓ |
Tumor cell proliferation |
[73] |
|
GSDMD↓ |
Poor prognosis in CRC |
[93] |
|
GSDME↑ |
Increase proliferation |
[94] |
Lung cancer |
GSDMD↑ |
Tumor proliferation |
[95,96] |
|
Knocking out GSDME |
Flip from apoptosis to pyroptosis |
[97] |
Cervical cancer |
Caspase-1↑ |
Lower tumor weight and volume |
[105] |
|
GSDMD↑ |
Lower tumor weight and volume |
[92,105] |
|
NLRP3↑ |
Lower tumor weight and volume |
[105,106] |
Ovarian cancer |
GSDME↓ |
OC progression |
[109] |
|
GSDMD↓ |
OC progression |
[110] |
|
Caspase-4↓ |
OC progression |
[110] |
Breast cancer |
GSDMB↑ |
Metastasis |
[117] |
|
GSDME↓ |
Metastasis |
[78] |
|
GSDMD↑ |
Caustic death |
[119] |
Skin cancer |
GSDMC↓ |
Invasion and metastasis |
[73] |