Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 19;297(6):1711–1740. doi: 10.1007/s00438-022-01954-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 12 — Potential phenotypic impacts of LTR7 and LTR5_Hs elements revealed by GSEA of 1944 high-fidelity down-steam target genes employing the Cell Marker Augmented 2021 database (A; B), the Allan Brain Atlas databases of up-regulated genes (C; D; G) and down-regulated genes (E; F; H). Left panel in B shows scatterplot visualization of GSEA results of the Cell Marker Augmented 2021 database of single-cell genomics-defined markers of human cells. Right panel in B reports top 30 significantly enriched records of gene sets identified by the GSEA of the Cell Marker Augmented 2021 database highlighting by stars gene expression signatures of human adult, embryonic, and cancer cells manifesting stemness phenotypes. Left panel in D shows scatterplot visualization of GSEA results of the Allan Brain Atlas database of up-regulated genes. Right panel in D reports top 30 significantly enriched records of gene sets identified by the Allan Brain Atlas database of up-regulated genes. Left panel in F shows scatterplot visualization of GSEA results of the Allan Brain Atlas database of down-regulated genes. Right panel in F reports top 30 significantly enriched records of gene sets identified by the Allan Brain Atlas database of down-regulated genes. Figure G shows side-by-side aligned scatterplots’ visualization of GSEA results of the 1944 LTR7- and/or LTR5_Hs-regulated genes (left panel; 324 significantly enriched records) and 1570 LTR7-regulated genes (right panel; 346 significantly enriched records) employing the Allan Brain Atlas database of up-regulated genes. Figure H shows side-by-side aligned scatterplots’ visualization of GSEA results of the 1944 LTR7- and/or LTR5_Hs-regulated genes (left panel; 178 significantly enriched records) and 1570 LTR7-regulated genes (right panel; 192 significantly enriched records) employing the Allan Brain Atlas database of down-regulated genes. In panels A, C, and E, results illustrating the top 10 significantly enriched records are reported. All reported significantly enriched records were identified at the significance threshold of adjusted p value < 0.05 by the GSEA of genes regulated by LTR7- and/or LTR5_Hs loci employing the corresponding genomic databases (Methods)