Fig. 7.

Identification and characterization LTR7 regulatory loci linked with genes whose products affect transmission across synapses and protein–protein interactions at synapses. Potential phenotypic impacts of 235 human regulatory LTR7 loci linked by the GREAT algorithm with 170 down-stream target genes revealed by interrogation of GO Cellular Component database (panel A; 46 significant terms), GO Molecular Function database (panel B; 64 significant terms), and GO Biological Process database (panel C; 146 significant terms). In contrast, analyses of 606 LTR5_Hs regulatory loci linked by GREAT with 935 gene identify 2 significantly enriched terms in GO Biological Process, GO Molecular Function, and Mouse Phenotype databases. Analyses were carried out using the GREAT algorithm designed to predict functions of cis-regulatory regions. Genomic coordinates of interrogated LTRs were based on the hg38 release of the human reference genome database