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. 2022 Sep 19;297(6):1711–1740. doi: 10.1007/s00438-022-01954-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Potential phenotypic impacts of 235 regulatory LTR7 loci revealed by interrogation of Mouse Phenotype Single KO database (panel A; 97 significant terms) and Mouse Phenotype database (panel B; 110 significant terms). Differential GO Molecular Function analyses of genetically and evolutionary distinct subfamilies of human regulatory LTR loci (panel C) comprising 168 and 235 LTR7 loci designed to highlight LTR7-linked phenotypic traits enriched in humans after separation of chimpanzee and human lineages (depicted by arrows are the kainate selective glutamate receptor activity and AMPA glutamate receptor activity). Analyses were carried out using the GREAT algorithm designed to predict functions of cis-regulatory regions. Genomics coordinates of LTR7 loci were based on the hg38 release of the human reference genome database