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Demonstration of the reduction in complexity of pharmacogenomic result interpretation by utilizing phenotype instead of genotype. In this example, 406 unique CYP2D6 genotype (diplotype) results (panel a) can be classified into four distinct phenotypes (panel b), with a small percentage left as indeterminate. This approach simplifies result interpretation for clinicians and enables clinical decision alerts to be triggered based on phenotype instead of diplotype.
