Table 1.

Summary of PRS Tools. Summary of PRS tools mentioned in this review, with required platform and input needed for analysis. ISC, International Schizophrenia Consortium; GCTB, genome-wide complex trait Bayesian analyses; LD, linkage disequilibrium; G/P, genotype/phenotype

Tool	Authors	Development Year	Platform	Input Requirements	Approach
P+T/C+T	ISC [56]	2009	PLINK	Base phenotype GWAS results Target G/P data	C+T
PRSice	Euesden et al. [41]	2015	R	Base phenotype GWAS results Target G/P data	C+T
LDpred	Vilhjálmsson et al. [44]	2015	R	Genetic architecture prior GWAS summary statistics LD reference panel Target G/P data	Bayesian (Gibbs Sampler)
PRS-CS	Ge et al. [45]	2019	Python	GWAS summary stats LD reference panel Target G/P data	Bayesian (Continuous Shrinkage)
SBayesR	Lloyd-Jones et al. [46]	2019	GCTB	GWAS summary stats LD reference panel Target G/P data	Bayesian (Gibbs Sampler)