Table 1.
Cohort demographics and characteristics
| Overall n = 151 | Tau negative n = 19 | LP n = 15 | MTL-sparing n = 27 | Typical n = 90 | |
| Age (y) | 72.9 (8.0) | 74.3 (6.4) | 75.9 (7.6) | 71.6 (10.6) | 72.5 (7.4) |
| Sex, F (%) | 72 (47.7) | 10 (52.6) | 5 (33.3) | 15 (55.6) | 42 (46.7) |
| Education (y) | 12.2 (3.0) | 12.5 (3.3) | 11.3 (2.6) | 12.6 (3.7) | 12.1 (2.8) |
| APOE ɛ4+ (%)* | 85 (56.3) | 11 (57.9) | 11 (73.3) | 7 (25.9) | 56 (62.2) |
| Centiloid† | 114.1 (41.6) | 62.7 (33.3) | 111.4 (37.5) | 111.7 (46.5) | 126.1 (33.6) |
| HV (cm3)‡ | 2.60 (0.3) | 2.64 (0.4) | 2.56 (0.2) | 2.90 (0.3) | 2.52 (0.3) |
| MCI n (%) | 67 (44.4) | 12 (63.2) | 10 (66.7) | 11 (40.7) | 34 (37.8) |
| Dementia n (%) | 84 (55.6) | 7 (36.8) | 5 (33.3) | 16 (59.3) | 56 (62.2) |
APOE, Apolipoprotein E; HV, hippocampal volume; MCI, mild cognitive impairment; LP, limbic predominant; MTL-sparing, mesial temporal lobe sparing. * APOE genotype was available for 17/19 tau negative, 13/15 LP, 23/27 MTL-sparing, and 69/90 Typical subgroup participants. p < 0.05, MTL-sparing versus LP; p < 0.05 MTL-sparing versus Typical. † p < 0.001, tau negative versus LP; p < 0.001 tau negative versus MTL-sparing; p < 0.001 tau negative versus Typical. ‡ HV was available for 18/19 tau negative, 12/15 LP, 21/27 MTL-sparing, and 84/90 Typical participants. p = 0.02, MTL-sparing versus LP; p < 0.001, MTL-sparing versus AD.