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. 2022 Sep 5;13:923448. doi: 10.3389/fendo.2022.923448

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Copyright © 2022 Esposito, Vigone, Polizzi, Wasniewska, Cassio, Mussa, Gastaldi, Di Mase, Vincenzi, Pozzi, Peroni, Bravaccio, Capalbo, Bruzzese and Salerno

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum concentrations of TSH (A), FT4 (B) and L-T4 dose (C) in CH patients divided in the two treatment groups throughout the study. According to study protocol, thyroid hormones levels were evaluated at the enrollment, 10 days after L-T4 start and subsequently at the chronological age of 1.5, 3, 6, 9, 12, 18, 24, 30, 36, 42 and 48 months of life. * Changes in TSH and FT4 levels and in L-T4 dose at the age of 3 years are due to L-T4 withdrawal in the majority of patients for the re-evaluation thyroid function.