Spatial learning ability (traveled distance). (A) Comparison among each of the four groups. TBI + Fx demonstrated greater distance than sham on Days 15, 16, and 17. Also, TBI + Fx showed significant worsening compared to isolated TBI on Days 15 and 17. EXT treatment corrected the length on Day 15. *p < 0.05, #p < 0.01 vs. sham, **p < 0.05, ##p < 0.01 vs. TBI only, ***p < 0.05 vs. CCI + BF + ENX. (B) Comparison among each of the 4 days. Sham and isolated TBI demonstrated significant improvement of the distance, but TBI + Fx and ENX groups were similar throughout 4 day’s trajectory. ^p < 0.05, &p < 0.01 vs. Day 14.