Table 5.
Beta-blockers indicated in HFrEF
| Beta-blocker | Initiation dose (mg) | Target dose (mg) |
| Bisoprolol | 1.25 once daily | 10 once daily |
| Carvedilol | 3.125 two times a day | 25–50 two times a day* |
| Metoprolol succinate (CR/XL)† | 12.5 once daily | 200 once daily |
| Nebivolol | 1.25 once daily | 10 once daily |
*50 mg two times a day if weight >85 kg.
†Extended-release preparations not available in the UK—no data to support the use of standard-release preparations of metoprolol tartarate.
HFrEF, heart failure with reduced ejection fraction.